反応 #76284

反応方程式

hydrogen

2-chloro-4-nitrobenzoic acid

acetone

→

4-Amino-2-chlorobenzoic Acid

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   その他to remove the catalyst
3. 3
   workup.DISTILLATIONThe solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2)

実験手順

In ethanol (250 mL) was dissolved 100 g (F.W. 201.57, 496 mmol) of 2-chloro-4-nitrobenzoic acid (1) and after replacing with argon, a 10% palladium carbon catalyst (4.0+1.5 g) was added thereto. After replacing with hydrogen, the mixture was stirred at room temperature for 72 hours. The formed crystal was dissolved with acetone and filtered to remove the catalyst. The solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2).

出典