反応 #7628

反応方程式

acetylchloride

2,6-diamino-4-chloro-pyrimidine

cyclohexylisonitrile

thiophene-2-carbaldehyde

→

1-acetyl-5-amino-7-chloro-3-cyclohexylamino-2-thiophene-2-yl-imidazo[1,2-a]pyrimidin-1-ium chloride

溶媒

perchloric acid

反応条件

実験手順

Example 26 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) thiophene-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典