反応 #76109

反応方程式

2-[4-(2-heptylamino-ethyl)-phenylamino]-2-methyl-propionic acid

2,4-difluorophenyl isocyanate

N,N-diisopropylethylamine

→

2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenylamino)-2-methyl-propionic acid

収率 8.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   濃縮concentrated under reduced pressure
2. 2
   その他purified by flash column chromatography (3% methanol/chloroform)

実験手順

A solution of of 2-[4-(2-heptylamino-ethyl)-phenylamino]-2-methyl-propionic acid (75 mg, 234 μmol), 2,4-difluorophenyl isocyanate (33 μL, 281 μmol), N,N-diisopropylethylamine (82 μL, 468 μmol) and methylene chloride (0.5 mL) was stirred at ambient temperature for 18 h, concentrated under reduced pressure and purified by flash column chromatography (3% methanol/chloroform) to provide 8.6 mg (8%) of 2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenylamino)-2-methyl-propionic acid as a white foam.

出典