反応 #75985

反応方程式

diethyl 2-(acetylamino)-2-(3-nitrobenzyl)malonate

hydrochloric acid

→

3-nitrophenylalanine hydrochloride

反応条件

後処理

1. 1
   workup.DISSOLUTIONthe suspension dissolves when hot
2. 2
   温度The reaction mixture is then cooled to a temperature in the region of 0° C.
3. 3
   ろ過finally filtered through a sinter funnel
4. 4
   洗浄The filter cake is washed with twice 50 cm3 of filtrate
5. 5
   その他dried in a fume cupboard
6. 6
   その他in the region of 60° C

実験手順

A suspension of 34 g of diethyl 2-(acetylamino)-2-(3-nitrobenzyl)malonate in 510 cm3 of concentrated hydrochloric acid is heated at a temperature in the region of 100° C. for 18 hours: a vigorous evolution of gas takes place and the suspension dissolves when hot. The reaction mixture is then cooled to a temperature in the region of 0° C., after which it is stirred for 1 hour at 0° C. and finally filtered through a sinter funnel. The filter cake is washed with twice 50 cm3 of filtrate and dried in a fume cupboard and then in an oven under vacuum (10 Pa) at a temperature in the region of 60° C. 23.4 g of 3-nitrophenylalanine hydrochloride are obtained in the form of white crystals melting at 222° C.

出典