反応 #7598

反応方程式

4,6-dichlorocinnoline

2-fluoro-5-hydroxy-4-methylaniline

→

6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride

収率 95.8%

溶媒

2-pentanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 45 minutes
3. 3
   温度After cooling the solid
4. 4
   ろ過was filtered off
5. 5
   洗浄washed with isopropanol

実験手順

A solution of 4,6-dichlorocinnoline (200 mg, 1 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (169 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (4 ml) containing 7M isopropanolic hydrogen chloride (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride (326 mg, 95%).

出典