反応 #75953
ord-d5f1d0d3073d452b8ad7c8c476d8d731
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他resulting two-phase mixture
- 2抽出extracted with ethyl acetate
- 3洗浄The combined organic extracts were washed with brine
- 4乾燥dried over anhydrous sodium sulfate
- 5その他evaporated
実験手順
A solution of sulfuryl chloride (12.4 mmol) in toluene (5 mL) was added dropwise via an additional funnel to a solution of ethyl isobutyrylacetate (12.4 mmol) in toluene (20 mL) over 5 minutes at room temperature. The resulting mixture was stirred at room temperature overnight. Water was added slowly and resulting two-phase mixture was basified with saturated NaHCO3 and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, and evaporated to afford 2.2 g (84%) of product as a pale yellow oil: MH+=227.0, retention time (LC-MS)=2.77 min.