反応 #75876

反応方程式

Amlodipine free base

Nicotinic acid

amlodipine

→

amlodipine nicotinate

収率 85.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The mixture was heated
2. 2
   温度at reflux
3. 3
   workup.DISSOLUTIONwas completely dissolved
4. 4
   その他The solids formed
5. 5
   その他were isolated by filtration
6. 6
   洗浄washed with ethyl acetate
7. 7
   その他dried under reduced pressure

実験手順

Amlodipine free base (4.09 g) was added to 40 mL of ethanol. The mixture was heated at reflux and stirred until the solid was completely dissolved. Nicotinic acid (1.23 g) was added to the amlodipine solution and then the mixture was slowly cooled down to 0° C. within one hour. The solids formed were isolated by filtration, washed with ethyl acetate and dried under reduced pressure to yield 4.51 g of amlodipine nicotinate.

出典