反応 #7580

反応方程式

4-chloro-7-methoxycinnoline hydrochloride

3-hydroxy-4-methylaniline

→

4-(3-hydroxy-4methylanilino)-7-methoxycinnoline

溶媒

2-pentanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 2 hours
3. 3
   温度After cooling
4. 4
   ろ過the solid was filtered off
5. 5
   洗浄washed with isopropanol, ether
6. 6
   その他dried under vacuum

実験手順

A suspension of 4-chloro-7-methoxycinnoline hydrochloride (196 mg, 0.85 mmol) and 3-hydroxy-4-methylaniline (123 mg, 1 mmol) in 2-pentanol (5 ml) was heated at reflux for 2 hours. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(3-hydroxy-4methylanilino)-7-methoxycinnoline as the hydrochloride salt (yellow solid, 215 mg, 80%).

出典