反応 #7577

反応方程式

sodium hydroxide

4-fluoro-2-methyl-5-nitrophenol

→

2-fluoro-5-hydroxy-4-methylaniline

収率 47.0%

溶媒

water

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 4 hours
3. 3
   温度to cool
4. 4
   抽出extracted with ethyl acetate (100 ml)
5. 5
   抽出The ethyl acetate extract
6. 6
   乾燥was dried (MgSO4)
7. 7
   その他the solvent removed by evaporation

実験手順

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

出典