反応 #7575

反応方程式

Methyl chloroformate

4-fluoro-2-methylphenol

→

4-fluoro-2-methylphenyl methyl carbonate

収率 78.4%

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate (100 ml)
2. 2
   抽出The ethyl acetate extract
3. 3
   洗浄was washed with water (100 ml)
4. 4
   乾燥dried (MgSO4)
5. 5
   その他the solvent removed by evaporation

実験手順

Methyl chloroformate (6.8 ml, 88 mmol) was added over 30 minutes to a solution of 4-fluoro-2-methylphenol (10 g, 79 mmol) in 6% aqueous sodium hydroxide solution at 0° C. The mixture was stirred for 2 hours, then extracted with ethyl acetate (100 ml). The ethyl acetate extract was washed with water (100 ml) and dried (MgSO4) and the solvent removed by evaporation to give 4-fluoro-2-methylphenyl methyl carbonate (11.4 g, 78%) as an oil.

出典