反応 #75747

反応方程式

hydrogen

N4-(2-methylpropyl)-3-nitro[1,5]naphthyridin-4-amine

→

N4-(2-methylpropyl)[1,5]naphthyridin-3,4-diamine

溶媒

ethyl acetate

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered
2. 2
   その他to remove the catalyst
3. 3
   濃縮the filtrate was concentrated under vacuum

実験手順

A catalytic amount of 5% platinum on carbon was added to a solution of N4-(2-methylpropyl)-3-nitro[1,5]naphthyridin-4-amine (1.0 g, 4.1 mmol) in ethyl acetate (50 mL). The reaction mixture was reduced on a Parr apparatus at 50 psi (3.5 Kg/cm2) hydrogen for four hours. The reaction mixture was filtered to remove the catalyst and the filtrate was concentrated under vacuum to provide N4-(2-methylpropyl)[1,5]naphthyridin-3,4-diamine as a crude solid.

出典