反応 #75737

反応方程式

Dimethylformamide diethyl acetal

3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylic acid

→

ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄then washed six times with water (500 mL)
2. 2
   乾燥dried over magnesium
3. 3
   濃縮concentrated under vacuum
4. 4
   その他The residue was recrystallized from ethyl acetate/hexanes

実験手順

Dimethylformamide diethyl acetal (46 mL) was added to a suspension of 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylic acid (36 g) in dichloromethane (800 mL). The reaction mixture was stirred at ambient temperature overnight then washed six times with water (500 mL), dried over magnesium sulfated, and concentrated under vacuum. The residue was recrystallized from ethyl acetate/hexanes to provide 40 g of ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate as a solid.

出典