反応 #75727

反応方程式

acetamide

2,2,2-Tribromo-N-(5,8-difluoro-2-methyl-quinolin-4-yl)-acetamide

3-chloro-4-methoxyaniline

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Title compound

収率 5.3%

1-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-urea

収率 5.3%

溶媒

pyridine

反応条件

実験手順

Title compound (0.005 g) was prepared according to the method of Example 66 from acetamide D23 (0.118 g) and 3-chloro-4-methoxyaniline (0.039 g) but using pyridine as solvent. m/z (API+): 378 (MH+). 1H NMR δ: 2.62 (3H, s), 3.83 (1H, s), 7.13 (1H, d, J=9.0 Hz ), 7.28-7.40 (2H, m), 7.50-7.60 (1H, m), 7.74 (1H, d, J=2.6 Hz), 8.29 (1H, s), 8.86 (1H, d), 9.93 (1H, s).

出典