反応 #7565

反応方程式

4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline

4-bromo-2-fluoroaniline

→

4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline

溶媒

DMF

反応条件

後処理

1. 1
   温度After cooling to ambient temperature the mixture
2. 2
   workup.ADDITIONwas treated

実験手順

A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.2 g, 0.74 mmol), (prepared as described for the starting material in Example 2), and 4-bromo-2-fluoroaniline (155 mg, 0.82 mmol) in DMF (2.5 ml) was heated at 150° C. for 45 minutes. After cooling to ambient temperature the mixture was treated as described in Example 3 to give 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (150 mg, 44%).

出典