反応 #75644

反応方程式

3,5-dichloroaniline

ethylglyoxalate

3-fluorostyrene

trifluoroacetic acid

→

Compound 8

収率 44.0%

5,7-dichloro-4-(3-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid Ethyl Ester

収率 44.0%

溶媒

acetonitrile

反応条件

実験手順

Compound 8 was prepared in a yield of 44% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 3-fluorostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

出典