反応 #7561

反応方程式

4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline

3-hydroxy-4-methylaniline

isopropanol

→

4-(3-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline

溶媒

DMF

反応条件

後処理

1. 1
   温度After cooling
2. 2
   ろ過the resulting solid filtered off
3. 3
   洗浄washed with isopropanol
4. 4
   その他dried under vacuum

実験手順

A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.4 g, 1.5 mmol) and 3-hydroxy-4-methylaniline (0.2 g, 1.6 mmol) in DMF (5 ml) was heated at 150° C. for 20 minutes. After cooling, isopropanol (15 ml) was added and the resulting solid filtered off, washed with isopropanol and dried under vacuum to give 4-(3-hydroxy-4-methylanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (yellow solid, 537 mg 91%).

出典