反応 #7549

反応方程式

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol

L-tartaric acid

ethanol

→

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol L-tartrate

収率 91.8%

溶媒

ethyl acetate

ethyl acetate

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   workup.DISSOLUTIONdissolution
3. 3
   workup.STIRRINGat the same temperature and the resulting mixture was stirred at 20 to 30° C. for 1 hour
4. 4
   その他The crystals precipitated
5. 5
   ろ過were collected by filtration

実験手順

In 40 mL of ethyl acetate was dissolved 10.0 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, and 5.15 g of L-tartaric acid and 40 mL of ethanol were added thereto, after which the resulting mixture was heated at 65° C. to effect dissolution. After the resulting solution was stirred at 50° C. for 20 minutes, 40 mL of ethyl acetate was added dropwise thereto at the same temperature and the resulting mixture was stirred at 20 to 30° C. for 1 hour. The crystals precipitated were collected by filtration to obtain 13.9 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol L-tartrate as colorless crystals.

出典