反応 #75484

反応方程式

3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone

guanidine

→

4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine

反応条件

後処理

1. 1
   その他This compound was prepared
2. 2
   温度in refluxing 2-methoxethanol

実験手順

This compound was prepared by heating equimolar amounts of 3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone and guanidine in refluxing 2-methoxethanol. 1H-NMR (300 MHz, CDCl3) δ2.67 (s, 3H, CH3), 2.68 (s, 3H, CH3), 5.14 (br, 2H, NH2), 6.83 (d, 1H, J=5.3 Hz, pyrimidinyl-H), 8.30 (d, 1H, J=5.3 Hz, pyrimidinyl-H).

出典