反応 #7547

反応方程式

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol

maleic acid

→

1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate

収率 88.4%

溶媒

acetone

反応条件

後処理

1. 1
   workup.ADDITIONby adding
2. 2
   workup.DISSOLUTIONdissolution
3. 3
   温度The reaction mixture was slowly cooled
4. 4
   その他The crystals precipitated
5. 5
   ろ過were collected by filtration

実験手順

In 56 mL of acetone was dissolved 8.00 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, followed by adding thereto 3.19 g of maleic acid, and the resulting mixture was heated at 60° C. to effect dissolution. The reaction mixture was slowly cooled and then stirred at 5° C. for 30 minutes. The crystals precipitated were collected by filtration to obtain 9.89 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate as colorless crystals.

出典