反応 #75438

反応方程式

5-methyl-4-hexenoic acid

diazomethane

→

title product

Methyl 5-methyl-4-hexenoate

溶媒

ether

ether

反応条件

後処理

1. 1
   その他The solvent was then evaporated under vacuum

実験手順

Freshly prepared diazomethane in ether was added to an ice-cooled solution of 5-methyl-4-hexenoic acid (4.5 g, 35.16 mmol) in ether (10 mL) until the solution became slightly yellow in color. The solvent was then evaporated under vacuum to afford the title product as a colorless liquid in near quantitative yield (4.90 g). This product was used in the next reaction step without further purification. 1H NMR (CDCl3) δ1.62 & 1.68[2s, 6H, C(CH3)2], 2.30[m, 4H, (CH2)2], 3.69(s, 3H, COOCH3) and 5.07(t, 1H, CH).

出典