反応 #75410

反応方程式

L-proline

sodium carbonate

3-(acetylthio)-2-(methylthiomethyl)propanoic acid chloride

acid

3-(acetylthio)-2-(methylthiomethyl)propanoic acid

thionyl chloride

→

1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONis added
2. 2
   抽出After extraction with ethyl acetate
3. 3
   抽出extracted with ethyl acetate
4. 4
   その他The organic layer is dried
5. 5
   濃縮concentrated to dryness in vacuo

実験手順

To a solution of L-proline (1.44 g.) and sodium carbonate (2.7 g.) in water (25 ml.) in an ice bath, 3-(acetylthio)-2-(methylthiomethyl)propanoic acid chloride (prepared from the acid of Example 15 with thionyl chloride) (3.6 g.) is added, and the mixture is vigorously stirred at room temperature for two hours. After extraction with ethyl acetate, the aqueous layer is acidified and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness in vacuo to give 1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline.

出典