反応 #75395

反応方程式

7,7-dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

2-(3,4-dimethoxy-phenyl)-ethylamine

→

7,7-Dimethyl-2-phenethyl-5-[2-(2-(3,4-dimethoxy-phenyl)ethylamino)-ethyl]-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione dihydrochloride

溶媒

ether

反応条件

後処理

1. 1
   温度After cooling
2. 2
   抽出extracted with water
3. 3
   その他The organic phase was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in acetone
5. 5
   その他The dihycrochloride was precipitated from the acetone solution with ethereal hydrochloric acid

実験手順

2.8 gm of 7,7-dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione were heated at 150° C. for 40 minutes with 5 ml of 2-(3,4-dimethoxy-phenyl)-ethylamine. After cooling, the mixture was dissolved in ether, and the solution was several times extracted with water weakly acidified with acetic acid. The organic phase was evaporated, and the residue was dissolved in acetone. The dihycrochloride was precipitated from the acetone solution with ethereal hydrochloric acid.

出典