反応 #7527

反応方程式

2-chloro-4-methoxybenzyl alcohol

triethylamine

methanesulfonyl chloride

→

title compound

収率 61.0%

2-chloro-4-methoxybenzyl chloride

収率 61.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他The solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONthe obtained residue was dissolved in ethyl acetate
3. 3
   洗浄The organic layer was washed with saturated brine
4. 4
   乾燥dried over anhydrous sodium sulfate
5. 5
   その他The solvent was evaporated under reduced pressure

実験手順

To a solution of 2-chloro-4-methoxybenzyl alcohol (1.5 g, 8.7 mmol) in dichloromethane (10 mL) were added under ice-cooling triethylamine (2.4 mL, 17.4 mmol) and methanesulfonyl chloride (0.74 mL, 9.5 mmol) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.01 g, 61%).

出典