反応 #7515

反応方程式

water

ethyl 4-chloro-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

sodium carbonate

4-fluorobenzylamine

→

title compound

収率 81.2%

ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-fluorobenzyl)amino]-5-pyrimidinecarboxylate

収率 81.2%

溶媒

isopropanol

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度under reflux for 18 h
3. 3
   ろ過The precipitated crystals were collected by filtration
4. 4
   洗浄washed several times with cold water and cold ether
5. 5
   その他dried

実験手順

To a solution of ethyl 4-chloro-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (607 mg, 2.0 mmol) in isopropanol (5 mL) were added sodium carbonate (424 mg, 4 mmol) and 4-fluorobenzylamine (313 mg, 4 mmol) and the mixture was heated under reflux for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether and dried to give the title compound (637 mg, 81%).

出典