反応 #75146

反応方程式

1-bromo-3-chloro-2-methylpropane

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

sodium hydroxide

→

1-(3-chloro-2-methylpropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one

収率 90.6%

反応条件

後処理

1. 1
   温度The reaction mixture is cooled
2. 2
   workup.ADDITIONpoured onto water
3. 3
   抽出the product is extracted with methylbenzene
4. 4
   その他The extract is dried
5. 5
   ろ過filtered
6. 6
   その他evaporated

実験手順

To a stirred mixture of 17.4 parts of 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one, 5-parts of N,N,N-triethyl benzenemethanaminium chloride and 180 parts of sodium hydroxide solution 60% are added dropwise 21 parts of 1-bromo-3-chloro-2-methylpropane while heating at 55° C. Upon completion, stirring at 55° C. is continued for 3 hours. The reaction mixture is cooled, poured onto water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 24 parts (90.6%) of 1-(3-chloro-2-methylpropyl)-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one as a residue.

出典