反応 #75122

反応方程式

1,3-dihydro-1-(3-hydroxypropyl)-5-(trifluoromethyl)-2H-benzimidazol-2-one

sulfinyl chloride

→

1-(3-chloropropyl)-1,3-dihydro-5-(trifluoromethyl)-2H-benzimidazol-2-one

収率 56.0%

溶媒

trichloromethane

反応条件

後処理

1. 1
   温度Upon completion, the whole is heated
2. 2
   温度to reflux
3. 3
   温度at reflux temperature
4. 4
   温度After cooling
5. 5
   その他the reaction mixture is evaporated
6. 6
   その他the residue is crystallized from 2,2'-oxybispropane

実験手順

To a stirred mixture of 23 parts of 1,3-dihydro-1-(3-hydroxypropyl)-5-(trifluoromethyl)-2H-benzimidazol-2-one in 150 parts of trichloromethane are added dropwise 32 parts of sulfinyl chloride. Upon completion, the whole is heated to reflux and stirring is continued for 1 hour at reflux temperature. After cooling, the reaction mixture is evaporated and the residue is crystallized from 2,2'-oxybispropane, yielding 14 parts (56%) of 1-(3-chloropropyl)-1,3-dihydro-5-(trifluoromethyl)-2H-benzimidazol-2-one.

出典