反応 #7511

反応方程式

water

ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

potassium carbonate

4-fluorobenzylbromide

→

title compound

収率 79.2%

ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-fluorobenzyl)oxy]-5-pyrimidinecarboxylate

収率 79.2%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   ろ過The precipitated crystals were collected by filtration
3. 3
   洗浄washed several times with cold water and cold ether
4. 4
   その他dried

実験手順

To a solution of ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (7.1 g, 27.6 mmol) in N,N-dimethylformamide (100 ml) were added potassium carbonate (7.8 g, 60 mmol) and 4-fluorobenzylbromide (3.74 ml, 30 mmol) and the mixture was stirred at 80° C. for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether and dried to give the title compound (8.6 g, 79%).

出典