反応 #75091

反応方程式

3-tert. butyl-4-phenyl isocarbostyril

phosphorous oxychloride

→

3-tert.butyl-1-chloro-4-phenyl isoquinoline

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of 11 g
2. 2
   その他The excess solvent is removed in vacuo and ice
3. 3
   workup.ADDITIONis added to the residue
4. 4
   ろ過The resulting solid is filtered
5. 5
   洗浄washed with water
6. 6
   その他recrystallized from ethanol

実験手順

A mixture of 11 g. (0.04 mole) of 3-tert. butyl-4-phenyl isocarbostyril and 40 ml. of phosphorous oxychloride is refluxed for one hour. The excess solvent is removed in vacuo and ice is added to the residue and stirred. The resulting solid is filtered and washed with water and recrystallized from ethanol to give 3-tert.butyl-1-chloro-4-phenyl isoquinoline; m.p. 139°-140° C.

出典