反応 #7507
ord-825838bf0675463188070eeb1a8507bd
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1洗浄The product was washed twice with water (40 ml)
- 2その他dried on Na2SO4
- 3その他The catalyst was removed by flash-chromatography on silica gel with CH2Cl2 as eluant
実験手順
A solution of 19-nortestosterone (10.0 g, 35.5 mmol) in dichloromethane (100.0 ml) was mixed with the catalyst previously prepared from RhCl3.H2O (380 mg) and Aliquat-336® (800 mg) in water (10.0 ml) and dichloromethane (22.0 ml). The mixture was hydrogenated overnight at 20 psi. The product was washed twice with water (40 ml) and dried on Na2SO4. The catalyst was removed by flash-chromatography on silica gel with CH2Cl2 as eluant to give 10.5 g (92% yield) the title compound as a white solid.