反応 #75037

反応方程式

Ethyl chloroformate

2-amino-4-methyloxazole

triethylamine

→

Ethyl N-(4-methyl-2-oxazolyl)carbamate

溶媒

ether

反応条件

後処理

1. 1
   ろ過the white solid was filtered off
2. 2
   洗浄washed well with water
3. 3
   その他to remove triethylamine hydrochloride
4. 4
   その他Residue (0.5 g) was recrystallised from chloroform-petroleum spirit, m.p. 126° C.

実験手順

Ethyl chloroformate (1.05 ml, 0.011 mol) was added dropwise to a stirred solution of 2-amino-4-methyloxazole (1.0 g, 0.010 mol) and triethylamine (1.5 ml, 0.011 mol) in dry ether (50 ml) at 5°-10° C. The mixture was stirred for 2 hours at 0°-5° C. then the white solid was filtered off and washed well with water to remove triethylamine hydrochloride. Residue (0.5 g) was recrystallised from chloroform-petroleum spirit, m.p. 126° C.

出典