反応 #75032

反応方程式

Potassium tetrachloroplatinite

1,2-diaminocyclohexane

→

Dichloro (1,2-diaminocyclohexane)platinum (II)

収率 90.0%

溶媒

water

反応条件

後処理

1. 1
   その他The insoluble product was removed by filtration
2. 2
   洗浄washed with water
3. 3
   乾燥with methanol, and oven-dried
4. 4
   その他The product was then purified by dissolution in dimethylformamide
5. 5
   ろ過filtration, and addition of three volumes of methanol or 0.1 N HCl
6. 6
   ろ過This product was filtered
7. 7
   洗浄washed
8. 8
   その他dried as above
9. 9
   その他The yield in purification

実験手順

Dichloro (1,2-diaminocyclohexane)platinum (II) was synthesized as described by Gale et al, Research Communications in Chemical Pathology and Pharmacology, Volume 7, No. 3, Pages 529-538, March 1974. Thus, Potassium tetrachloroplatinite, K2Pt Cl4 (20 mM) in 75 ml water was mixed with 1,2-diaminocyclohexane (20 mM) for three hours at room temperature. The insoluble product was removed by filtration, washed with water and then with methanol, and oven-dried. The yield was approximately 90% of theory. The product was then purified by dissolution in dimethylformamide, filtration, and addition of three volumes of methanol or 0.1 N HCl. This product was filtered, washed, and dried as above. The yield in purification was 47%.

出典