反応 #75012

反応方程式

3,4-dihydro-2-methyl-3-oxo-2H-thieno[2,3-e]1,2-thiazine 1,1-dioxide

dimethylsulfoxide

4-bromophenyl isocyanate

→

4'-bromo-3-hydroxy-2-methyl-2H-thieno[2,3-e]1,2-thiazine-4-carboxanilide 1,1-dioxide

溶媒

triethylamine

反応条件

後処理

1. 1
   workup.ADDITIONThis mixture is then poured into 225 ml
2. 2
   ろ過of 3-N hydrochloric acid and the prepcipitate which separates out is filtered on a sinter
3. 3
   ろ過filter
4. 4
   洗浄washed three times with 20 ml
5. 5
   乾燥of distilled water each time and dried as much as possible
6. 6
   workup.DISSOLUTIONThe precipitate is dissolved in 250 ml
7. 7
   乾燥of methylene chloride, dried over sodium sulfate
8. 8
   workup.STIRRINGstirred with activated charcoal
9. 9
   ろ過filtered
10. 10
    workup.STIRRINGThe organic phase is shaken out four times with 250 ml
11. 11
    workup.STIRRINGof saturated sodium bicarbonate solution each time and the aqueous phase is shaken again each time with a little methylene chloride
12. 12
    抽出The product which separates out is extracted three times with 250 ml
13. 13
    乾燥The combined organic phases are dried over sodium sulfate
14. 14
    workup.STIRRINGstirred with activated charcoal
15. 15
    ろ過filtered
16. 16
    その他the solvent is removed by distillation
17. 17
    workup.DISSOLUTIONThe crystalline residue is dissolved in 50 ml
18. 18
    workup.ADDITIONactivated charcoal is added
19. 19
    ろ過the mixture is filtered hot
20. 20
    その他to crystallize
21. 21
    その他The crystals are removed by filtration
22. 22
    その他is obtained

実験手順

3.1 G. of 3,4-dihydro-2-methyl-3-oxo-2H-thieno[2,3-e]1,2-thiazine 1,1-dioxide are dissolved in 31 ml. of absolute dimethylsulfoxide under an atmosphere of nitrogen. 1.44 G. of freshly distilled triethylamine and 2.83 g. of 4-bromophenyl isocyanate are added to the solution and the mixture is then stirred for 24 hours at room temperature. This mixture is then poured into 225 ml. of 3-N hydrochloric acid and the prepcipitate which separates out is filtered on a sinter filter, washed three times with 20 ml. of distilled water each time and dried as much as possible. The precipitate is dissolved in 250 ml. of methylene chloride, dried over sodium sulfate, stirred with activated charcoal and filtered. The organic phase is shaken out four times with 250 ml. of saturated sodium bicarbonate solution each time and the aqueous phase is shaken again each time with a little methylene chloride. The combined aqueous phases are rendered strongly acid with concentrated hydrochloric acid. The product which separates out is extracted three times with 250 ml. of methylene chloride each time. The combined organic phases are dried over sodium sulfate, stirred with activated charcoal, filtered and the solvent is removed by distillation. The crystalline residue is dissolved in 50 ml. of chloroform. While boiling, activated charcoal is added and the mixture is filtered hot. The product is made to crystallize by scratching. The crystals are removed by filtration, digested with a little cold chloroform, and 4'-bromo-3-hydroxy-2-methyl-2H-thieno[2,3-e]1,2-thiazine-4-carboxanilide 1,1-dioxide, melting point 178° C. to 179° C. (decomposition), is obtained.

出典