反応 #74993

ord-1bae79cdb4cd473f92543be6b20fce4c

反応方程式

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Rifamycin S

dimethylformamide

1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine

→

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rifampicin

反応物

1-amino-4-methylpiperazine

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Rifamycin S

dimethylformamide

1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine

試薬

なし

溶媒

acetic acid

反応条件

詳細条件

See reaction.notes.procedure_details.

後処理

1
workup.ADDITIONadded directly

実験手順

15 g. Rifamycin S are dissolved in 50 ml. dimethylformamide and 5.5 g. 1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine are added to the solution. The reaction mixture is then kept at 75° C. for about 3 hours and 1-amino-4-methylpiperazine, acidified with acetic acid, added directly according to the procedure described in Example 1, followed by analogous working up to give substantially pure rifampicin.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04174320uspto-grants-1979_11