反応 #74950

反応方程式

N- (2-chloro-benzyl)-2-(2-thienyl)ethylamine

Ethyl 2-chloro-2-ethoxy-acetate

→

desired product

5-(2-chloro-benzyl)-4-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine hydrochloride

溶媒

dimethylformamide

反応条件

実験手順

Into a three-necked 250 ml flask are added 25.1 g (0.1 M) N- (2-chloro-benzyl)-2-(2-thienyl)ethylamine dissolved in 30 ml dimethylformamide. Ethyl 2-chloro-2-ethoxy-acetate (18.3 g; 0.11 M) is then added over 6 minutes, and the resulting material is heated at 80° C. for 4 hours after which the desired product begins to precipitate out. After cooling of the medium, the product is filtered off and recrystallized from 3×20 ml acetone, to give 20.5 g 5-(2-chloro-benzyl)-4-ethoxy-carbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (Yield: 55%).

出典