反応 #74844

反応方程式

2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile

HCl

methanol

→

2-(p-Fluorobenzoyl)-3-hydroxycrotononitrile

反応条件

後処理

1. 1
   温度Upon cooling in an ice bath
2. 2
   その他a solid formed
3. 3
   その他was collected
4. 4
   その他recrystallized from cyclohexane-petroleum ether with charcoal treatment
5. 5
   その他giving 0.7 g

実験手順

A solution of 1.35 g. (0.006 m) of 2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile in a mixture of 15 ml. methanol and 8 ml. of 1 N HCl was heated on the steam bath in an open beaker for 45 minutes. Upon cooling in an ice bath, a solid formed, was collected, and then recrystallized from cyclohexane-petroleum ether with charcoal treatment, giving 0.7 g. (64%) of light pinkish crystals, m.p. 65°-67° C.

出典