反応 #74781

反応方程式

water

2,3-epoxy-1,2,3,4-tetrahydronaphthalene

2-pyridyl lithium

→

2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

溶媒

ether

反応条件

後処理

1. 1
   workup.ADDITIONAfter addition
2. 2
   workup.WAITto come to room temperature over several hours
3. 3
   温度cooled again
4. 4
   その他the product purified by chromatography in neutral alumina

実験手順

A solution of 25 g of 2,3-epoxy-1,2,3,4-tetrahydronaphthalene in 250 ml ether is added to a solution of 2-pyridyl lithium (prepared from 2-bromopyridine and butyllithium) cooled to -20° C. After addition, the mixture is allowed to come to room temperature over several hours, then cooled again and treated with water. The separated, dried organics are taken to dryness, and the product purified by chromatography in neutral alumina.

出典