反応 #74743

反応方程式

DMSO

2-Chloro-5-nitropyridine

2,2,2-trifluoroethanol

lithium hydroxide

→

2-(2,2,2-Trifluoroethoxy)-5-Nitropyridine

溶媒

water

反応条件

後処理

1. 1
   その他the product was separated by filtration
2. 2
   その他It was crystallized from ethyl acetate-hexanes, yield 5.0 grams
3. 3
   その他35°-37° C.

実験手順

2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.

出典