反応 #74718

反応方程式

NaBH4

2-Acetyl-3-chloro-furan

2-(1-hydroxyethyl)-3-chloro-furan

bromine

→

maltol

溶媒

water

methanol

反応条件

後処理

1. 1
   温度cooled to 5° C
2. 2
   温度dropwise and with cooling
3. 3
   workup.ADDITIONAfter the addition
4. 4
   温度was heated to 95° C. for 2 hours
5. 5
   workup.DISTILLATIONdistilling off a portion of the methanol
6. 6
   温度The reaction was then cooled

実験手順

2-Acetyl-3-chloro-furan (1.0 g, 7 mmoles) in 30 ml methanol was cooled to 10° C. and 0.065 g, (1.7 mmoles) of NaBH4 added in one portion. After stirring for 30 minutes at 25° C., the solution was treated with 15 ml of water and cooled to 5° C. To the formed 2-(1-hydroxyethyl)-3-chloro-furan was then added 1.1 g (7 mmoles) of bromine, dropwise and with cooling. After the addition was complete the reaction was heated to 95° C. for 2 hours, distilling off a portion of the methanol. The reaction was then cooled and maltol isolated by the method of Example 1.

出典