反応 #746448

ord-00c86bf1f0434c1686e045d62fca7415

反応方程式

N[C@@H]1CCC[C@@H]1N1CCCC1
cis-2-pyrrolidin-1-yl-cyclopentylamine
N[C@@H]1CCC[C@@H]1N1CCCC1
intermediate Q
N[C@@H]1CCC[C@@H]1N1CCCC1
cis-2-pyrrolidin-1-yl-cyclopentylamine
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)O
2-methoxy-4,6-bis(trifluoromethyl)benzoic acid
→
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)N[C@@H]1CCC[C@@H]1N1CCCC1
title compound
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)N[C@@H]1CCC[C@@H]1N1CCCC1
cis-2-Methoxy-N-(2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

反応物

N[C@@H]1CCC[C@@H]1N1CCCC1
cis-2-pyrrolidin-1-yl-cyclopentylamine
N[C@@H]1CCC[C@@H]1N1CCCC1
intermediate Q
N[C@@H]1CCC[C@@H]1N1CCCC1
cis-2-pyrrolidin-1-yl-cyclopentylamine
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)O
2-methoxy-4,6-bis(trifluoromethyl)benzoic acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound, white solid, MS: m/e=425.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-methoxy-4,6-bis(trifluoromethyl)benzoic acid.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08080541B2uspto-grants-2011_12