反応 #74508

反応方程式

compound 2

2,3,4,6-tetra-O-benzyl-D-glucopyranose

(5-bromo-2-chloro-4-methoxybenzyloxy)triisopropylsilane

compound 89

(5-bromo-2-chloro-4-methoxybenzyloxy)triisopropylsilane

2,3,4,6-tetra-O-benzyl-D-glucopyranose

→

title compound

(2-Chloro-4-methoxy-5-((3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)methanol

反応条件

実験手順

With similar method described in Step 3 of Example 92, (5-bromo-2-chloro-4-methoxybenzyloxy)triisopropylsilane (compound 89, 27.2 g, 66.7 mmol) and 2,3,4,6-tetra-O-benzyl-D-glucopyranose (compound 2, 30.0 g, 55.6 mmol) were converted to title compound (22.6 g, 59%, ca. 8:1 mixture of anomers (13:0) as a white solid.

出典