反応 #74507

反応方程式

5-bromo-2-chloro-4-methoxybenzonitrile

NaOH

EtOH

→

title compound

5-Bromo-2-chloro-4-methoxybenzoic acid

溶媒

water

反応条件

後処理

1. 1
   温度was refluxed overnight
2. 2
   その他EtOH was removed under reduced pressure
3. 3
   workup.ADDITIONThe mixture was diluted with water and neutralized with hydrochloric acid (3.0 N)
4. 4
   ろ過The resulting solid was filtered
5. 5
   その他dried in vacuo

実験手順

A mixture of 5-bromo-2-chloro-4-methoxybenzonitrile (30.7 g, 124 mmol) and NaOH (127 g, 3.11 mol) in EtOH (500 mL) and water (250 mL) was refluxed overnight. After cooling to room temperature, EtOH was removed under reduced pressure. The mixture was diluted with water and neutralized with hydrochloric acid (3.0 N). The resulting solid was filtered and dried in vacuo to give title compound (32.9 g, quantitative) as a white solid.

出典