反応 #744866

反応方程式

trifluoroacetic acid

solution

6-[(4-aminophenyl)ethynyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

3-chloro-phenyl isocyanate

triethylamine

→

trifluoroacetic acid

収率 17.3%

title compound

N-{4-[(7-amino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethynyl]phenyl}-N′-(3-chlorophenyl)urea

溶媒

CH3CN

CH3CN

反応条件

後処理

1. 1
   その他The resulting mixture was purified by reverse phase HPLC (C-18 column

実験手順

To a stirred solution of Example 1 (10 mg, 0.038 mmol) in 1.0 mL of CH3CN was added 3-chloro-phenyl isocyanate (6.4 mg, 0.046 mmol) and triethylamine (8 μL, 0.057 mmol). The resulting mixture was stirred for over night at room temperature. The resulting mixture was purified by reverse phase HPLC (C-18 column, eluting with a 5-100% CH3CN gradient in 0.1% trifluoroacetic acid) to the title compound as its trifluoroacetic acid salt (3.5 mg, 17.3% yield). MS (ESI) m/z 416, 418 (M+H)+.

出典