反応 #74417

反応方程式

ethyl 2-hydroxy-2,3-dimethylbutanoate

guanidine hydrochloride

K2CO3

→

product

2-Amino-5-isopropyl-5-methyl-1,3-oxazol-4(5H)-one

溶媒

ethanol

反応条件

後処理

1. 1
   温度under reflux for 20 h
2. 2
   その他The solvent was removed
3. 3
   その他the residue was purified by silica gel flash chromatography (ethyl acetate/methanol 9:1)

実験手順

A mixture of ethyl 2-hydroxy-2,3-dimethylbutanoate (2.92 g, 18.2 mmol), guanidine hydrochloride (1.74 g, 18.2 mmol), and K2CO3 (2.52 g, 18.2 mmol) in 99.5% ethanol (40 mL) was stirred under reflux for 20 h. The solvent was removed, and the residue was purified by silica gel flash chromatography (ethyl acetate/methanol 9:1) to give the product as a white solid.

出典