反応 #742984

反応方程式

nitric acid

2,6-dimethyl bromobenzene

→

yellow solid

2,6-Dimethyl-3-nitrobromo Benzene

溶媒

反応条件

後処理

1. 1
   温度cooled in an ice-bath (above f.p)
2. 2
   その他to come to rt
3. 3
   その他Reaction mixture
4. 4
   温度was cooled
5. 5
   ろ過The resulting yellow solid was filtered
6. 6
   洗浄washed with ice-water
7. 7
   その他dried

実験手順

Fuming nitric acid (83.3 mL) (>90%) was added slowly to a solution of 2,6-dimethyl bromobenzene (27.9 g, 150 mmol) in acetric acid (167 mL) and cooled in an ice-bath (above f.p). The mix was allowed to come to rt and later heated at 80° C. for 2 h. (HPLC showed no SM). Reaction mixture was cooled and poured into ice-water with stirring. The resulting yellow solid was filtered, washed with ice-water and dried to give 28.7 g of an yellow solid which was used as such in the next step.

出典