反応 #74280

反応方程式

1-(pyridin-4-yl)piperazine

N-benzyl-piperidinone

KCN

AcOH

→

1-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidine-4-carbonitrile

収率 47.0%

溶媒

methanol

water

反応条件

後処理

1. 1
   その他The reaction mixture was quenched with NH4OH solution (400 ml)
2. 2
   ろ過filtered
3. 3
   洗浄The solid precipitate was thoroughly washed with water
4. 4
   その他dried under vacuum
5. 5
   その他taken through to the next reaction without further purification

実験手順

A solution containing 1-(pyridin-4-yl)piperazine (58.34 mmol, 1 equiv.), N-benzyl-piperidinone (1 equiv.), KCN (1.1 equiv.), AcOH (3.3 ml) and water (1.3 ml) in methanol was stirred at room temperature for 16 h. The reaction mixture was quenched with NH4OH solution (400 ml) and filtered. The solid precipitate was thoroughly washed with water, dried under vacuum and taken through to the next reaction without further purification. Yield: 47%.

出典