反応 #74274

反応方程式

N-((1-benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

acetic acid

hydrogen

→

desired product

収率 90.0%

N-((4-(4-Cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

収率 90.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他for 10 min
2. 2
   ろ過The reaction mixture was filtered through celite
3. 3
   濃縮the filtrate was concentrated to dryness

実験手順

Through a solution of N-((1-benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide (5.4 mmol) in methanol (30 ml) was passed argon gas for 10 min. Then acetic acid (855 μl) and Pd(OH)2 (40% by weight) were added to the reaction mixture and it was stirred at room temperature for 16 h under an atmosphere of H2 by using a hydrogen balloon. The reaction mixture was filtered through celite and the filtrate was concentrated to dryness to yield the desired product which was used in the next step without further purification. Yield: 90%.

出典