反応 #742275

反応方程式

cefaclor

ammonia

→

cefaclor monohydrate

溶媒

water

反応条件

後処理

1. 1
   ろ過The suspension was filtered through a glass
2. 2
   ろ過filter
3. 3
   洗浄the wet cake was washed with 2×15 ml water and 2×15 ml acetone
4. 4
   その他After drying

実験手順

A crystallisation reactor was filled with 10 g water. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 30 minutes at 25° C. The pH was kept at 5.0 with ammonia. Subsequently, the suspension was stirred at 10° C. for another 30 min. The suspension was filtered through a glass filter and the wet cake was washed with 2×15 ml water and 2×15 ml acetone. After drying, 18.3 g cefaclor monohydrate was obtained (purity 99.6%).

出典