反応 #742274

反応方程式

cefaclor

cefaclor

ammonia

→

cefaclor monohydrate

溶媒

water

反応条件

後処理

1. 1
   その他30 min
2. 2
   その他at 30° C.
3. 3
   その他30 min
4. 4
   その他at 25° C.
5. 5
   その他60 min
6. 6
   その他at 20° C
7. 7
   ろ過The suspension was filtered through a glass
8. 8
   ろ過filter
9. 9
   洗浄the wet cake was washed with one volume of water and two volumes of acetone
10. 10
    その他After drying

実験手順

A crystallisation reactor was filled with 34 g water and 1.0 g cefaclor as seed. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 60 minutes at 35° C. The pH was kept at 5.0 with ammonia. Subsequently, the temperature was lowered in steps: 30 min at 30° C., 30 min at 25° C., and 60 min at 20° C. The suspension was filtered through a glass filter and the wet cake was washed with one volume of water and two volumes of acetone. After drying, 15.7 g cefaclor monohydrate was obtained (purity 99.4%).

出典