反応 #742252

反応方程式

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

dec-9-en-1-ol

→

colourless crystals

収率 21.5%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid dec-9-enyl ester

収率 21.5%

溶媒

ether

反応条件

後処理

1. 1
   その他removing the ethanol
2. 2
   その他formed
3. 3
   温度the reaction mixture was cooled
4. 4
   洗浄washed with brine
5. 5
   その他The organic phase was dried
6. 6
   その他evaporated to dryness
7. 7
   workup.DISTILLATIONThe resulting oil was Kugelrohr-distilled
8. 8
   その他crystallized
9. 9
   その他recrystallized

実験手順

A mixture of 5.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester, 6.1 g dec-9-en-1-ol and 1.0 g tetraisopropyl-ortho-titanate was heated to 150° C. removing the ethanol formed. After stirring for 2.5 hours at this temperature, the reaction mixture was cooled, diluted with ether and washed with brine. The organic phase was dried and evaporated to dryness. The resulting oil was Kugelrohr-distilled, crystallized and recrystallized to yield 1.69 g of colourless crystals.

出典