反応 #742251

反応方程式

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

potassium hydroxide

→

colourless crystals

収率 51.9%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid

収率 51.9%

溶媒

ethanol

water

反応条件

後処理

1. 1
   温度at reflux for 28 hours
2. 2
   濃縮the reaction mixture was concentrated
3. 3
   workup.ADDITIONThe residue was diluted with 500 ml HCl 2N
4. 4
   抽出extracted with ether
5. 5
   洗浄The organic phase was washed with 2N HCl and water
6. 6
   その他dried
7. 7
   その他evaporated to dryness
8. 8
   その他The resulting solid was recrystallized

実験手順

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

出典